Sanguinarine as an Antiparasitic against Helminths and Protozoa with Importance in Human and Veterinary Medicine: A Systematic Review
Maria Stéphanny de Souza Silva, Mayara Larissa Melo Ferreira dos Santos, Wilza Wanesssa Melo França, João Victor Ritinto da Rocha, Emily Gabriele Marques Diniz, Mary Angela Aranda de Souza, Wheverton Ricardo Correia do Nascimento, Mônica Camelo Pessoa de Azevedo Albuquerque, Iranildo José da Cruz Filho, Hallysson Douglas Andrade de Araújo, André de Lima Aires
Abstract
There is a constant search for new pharmacological alternatives, mainly of plant origin, for the treatment and control of parasites that compromise the health of humans and animals of economic importance. In this context, Sanguinarine (SA) stands out, an alkaloid with multiple pharmacological and biological properties, including antiparasitic properties. We sought to compile articles that explored plant extracts containing SA and/or SA isolated against helminths and/or protozoa with importance in human and veterinary medicine. This is a systematic review of the literature whose original articles were searched in electronic databases using the cross between health science descriptors and free terms between February and August 2023. Fifteen articles were found that report antiparasitic activity, in vitro and in vivo, against different species, such as Trichinella Spiralis, Dactylogyrus intermedius, Toxocara canis, trophozoites of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, Leishmania sp and Schistosoma mansoni. Furthermore, SA showed activity in lesions caused by parasites. The studies highlight the promising antiparasitic activity of SA against different species and genera of parasites with importance in human and veterinary medicine and we highlight the importance of continuing these studies that may include SA in the limited range of antiparasitic drugs.
Full Text: PDF DOI: 10.15640/ijhs.v11n2a15
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