International Journal of Health Sciences

Relation between Early Life Human Herpes Simplex Virus – I Infection and Food Allergy: An Animal Model in Balb/C Mice
Bora EKINCI, Ph.D.; Belma DURUPINAR, Ph.D.; Murat ERTURK, Ph.D.

Abstract
Impairment of consecutive immune reactions mediated by Th1 and Th2 lymphocytes cause failure of tolerance and emerged allergic disorders, have revealed hygiene hypothesis. It was aimed to investigate the effects of acute and latent HSV-I infections on allergy development. Balb/C mice, both acute or latent HSV-I infection and without infection, were sensitized with egg white and whey proteins and IL-4, TGF-β and IFN- γ cytokine responses were investigated in allergic and tolerant subjects. Cytokine responses revealed that, in the allergy, group IL-4 level was the highest and TGF- β level was significantly lower than acute infection group. In acute, latent and tolerance groups the cytokine levels were observed to be similar in contrast to allergy group. During acute infection, Th-1 lymphocyte cytokine response raised and Th2 response suppressed. Results were suggested, at early ages receiving HSV-I infection might compensate the disequilibrium between T helper subsets, and suppress allergy development.

Full Text: PDF     DOI: 10.15640/ijhs.v4n4a6